branched-chain 2-oxo acid dehydrogenase activity

Term ID

GO:0003863

Synonyms

• 2-oxoisocaproate dehydrogenase activity
• 2-oxoisovalerate (lipoate) dehydrogenase activity
• 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
• 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity
• 3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
• 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity
• alpha-keto-alpha-methylvalerate dehydrogenase activity
• alpha-ketoacid dehydrogenase activity
• alpha-ketoisocaproate dehydrogenase activity
• alpha-ketoisocaproic dehydrogenase activity
• alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity
• alpha-ketoisovalerate dehydrogenase activity
• alpha-oxoisocaproate dehydrogenase activity
• BCKDH activity
• BCOAD activity
• branched chain keto acid dehydrogenase activity
• branched-chain (-2-oxoacid) dehydrogenase (BCD) activity
• branched-chain 2-keto acid dehydrogenase activity
• branched-chain alpha-keto acid dehydrogenase activity
• branched-chain alpha-oxo acid dehydrogenase activity
• branched-chain keto acid dehydrogenase activity
• branched-chain ketoacid dehydrogenase activity
• dehydrogenase, 2-oxoisovalerate (lipoate) activity
• dehydrogenase, branched chain alpha-keto acid activity

Definition

Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H+ = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2. Also acts on 4-methyl-2-oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine. 1.2.4.4

References

• EC:1.2.4.4
• MetaCyc:1.2.4.4-RXN

Ontology

GO: Molecular Function    QuickGO    AmiGO