thapsigargin

Term ID

CHEBI:9516

Synonyms

(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate
octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester
Tg
Thapsigargin
thapsigargine

Definition

An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca²⁺-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.

References

cas:67526-95-8
kegg.compound:C09561
knapsack:C00003375
lipidmaps:LMPR0103410001
pdb-ccd:TG1
pubmed:10477042
pubmed:12410314
pubmed:16874404
pubmed:17825049
pubmed:20357004
pubmed:24598360
pubmed:9014219
reaxys:4649293
wikipedia.en:Thapsigargin

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from thapsigargin

Phenotype where environments contain thapsigargin

Phenotype modified by environments containing thapsigargin

Phenotype affecting thapsigargin

Human Disease Model