TW-37

Term ID

CHEBI:95008

Synonyms

N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]-benzamide
N-{4-[(2-tert-butylphenyl)sulfonyl]phenyl}-2,3,4-trihydroxy-5-[2-(propan-2-yl)benzyl]benzamide
TW 37
TW37

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of 2,3,4-trihydroxy-5-[2-(propan-2-yl)benzyl]benzoic acid with the amino group of 4-[(2-tert-butylphenyl)sulfonyl]aniline. It is a potent inhibitor of Bcl-2 family of proteins (Ki = 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL).

References

cas:877877-35-5
drugbank:DB17059
lincs.smallmolecule:LSM-6236
pubmed:16951185
pubmed:17404107
pubmed:18528859
pubmed:19220884
pubmed:19318573
pubmed:19372562
pubmed:20675079
pubmed:23832116
pubmed:25823945
pubmed:26958630
pubmed:28696828
pubmed:29065135
pubmed:29207200
pubmed:29631678
pubmed:30885150
pubmed:31052354
pubmed:32079453
pubmed:32163813
pubmed:32257914
pubmed:32863764
pubmed:33568941
pubmed:33951465
pubmed:36907299
pubmed:37385390
pubmed:37582646

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from TW-37

Phenotype where environments contain TW-37

Phenotype modified by environments containing TW-37

Phenotype affecting TW-37

Human Disease Model