Search Ontology:
ChEBI
tubastatin A
- Term ID
- CHEBI:94186
- Synonyms
-
- N-hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
- N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
- tubastatin-a
- Definition
- A pyridoindole that is 1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indole which is substituted on the tetrahydropyridine nitrogen by a methyl group and on the indole nitrogen by a p-[N-(hydroxy)aminocarbonyl]benzyl group. It is a histone deacetylase 6 (HDAC6) inhibitor that is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
- References
-
- cas:1252003-15-8
- lincs.smallmolecule:LSM-4806
- pubmed:20614936
- pubmed:23541634
- pubmed:24844691
- pubmed:24909686
- pubmed:25108326
- pubmed:25921924
- pubmed:26647018
- pubmed:26790818
- reaxys:20796421
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from tubastatin A
Phenotype where environments contain tubastatin A
Phenotype modified by environments containing tubastatin A
Phenotype affecting tubastatin A
Human Disease Model