Ro 25-6981

Term ID

CHEBI:92897

Synonyms

(alphaR,betaS)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol
4-[(1R,2S)-1-hydroxy-2-methyl-3-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol
4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
Ro 25-6981 free base
Ro-25-6981
Ro25-6981

Definition

A member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor.

References

cas:169274-78-6
chemspider:5037146
lincs.smallmolecule:LSM-3140
pdb-ccd:QEM
pubmed:11290368
pubmed:12498913
pubmed:14534359
pubmed:15081591
pubmed:15256539
pubmed:17970830
pubmed:18809426
pubmed:21598675
pubmed:21677647
pubmed:23113280
pubmed:24076088
pubmed:24893066
pubmed:25008524
pubmed:25446739
pubmed:27062927
pubmed:27456026
pubmed:27871866
pubmed:28802646
pubmed:29777135
pubmed:29790100
pubmed:29800545
pubmed:29862605
pubmed:32640759
pubmed:32925228
pubmed:34363521
pubmed:34453973
pubmed:34575558
pubmed:9400004
pubmed:9572302

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from Ro 25-6981

Phenotype where environments contain Ro 25-6981

Phenotype modified by environments containing Ro 25-6981

Phenotype affecting Ro 25-6981

Human Disease Model