Ro 25-6981

Term ID

CHEBI:92897

Synonyms

(alphaR,betaS)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol
4-[(1R,2S)-1-hydroxy-2-methyl-3-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol
4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
Ro 25-6981 free base
Ro-25-6981
Ro25-6981

(all 6)

Definition

A member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor.

References

(all 33)

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzenes phenols piperidines secondary alcohol tertiary amino compound

benzenes phenols piperidines secondary alcohol tertiary amino compound Show first 5 Terms
has_role: anticonvulsant antidepressant neuroprotective agent NMDA receptor antagonist

anticonvulsant antidepressant neuroprotective agent NMDA receptor antagonist Show first 5 Terms
inverse is_conjugate_acid_of: Ro 25-6981(1+)

Ro 25-6981(1+) Show first 5 Terms
is_conjugate_base_of: Ro 25-6981(1+)

Ro 25-6981(1+) Show first 5 Terms

Phenotype

Phenotype resulting from Ro 25-6981

Phenotype where environments contain Ro 25-6981

Phenotype modified by environments containing Ro 25-6981

Phenotype affecting Ro 25-6981

Human Disease Model