abexinostat

Term ID

CHEBI:92223

Synonyms

• 3-[(dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide
• 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide
• 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide
• 3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide
• abexinostat
• abexinostatum
• CRA 024781
• CRA 24781
• CRA-024781
• PCI 24781
• PCI-24781
• PZP-115891
• PZP115891
• S-78454
• S78454

Definition

A 1-benzofuran substituted by {2-[4-(hydroxycarbamoyl)phenoxy]ethyl}aminocarbonyl and (dimethylamino)methyl groups at positions 2 and 3, respectively. It is a potent pan-HDAC inhibitor whose major target is HDAC1 (Ki = 7 nM).

References

• agr:IND605480874
• cas:783355-60-2
• drugbank:DB12565
• hmdb:HMDB0256171
• kegg.drug:D10060
• lincs.smallmolecule:LSM-2269
• pmc:PMC4144576
• pubmed:16731764
• pubmed:18006784
• pubmed:18042714
• pubmed:19417021
• pubmed:19417023
• pubmed:20145726
• pubmed:20461381
• pubmed:21508354
• pubmed:22326466
• pubmed:23724141
• pubmed:23737346
• pubmed:23790467
• pubmed:23977108
• pubmed:24312289
• pubmed:25110436
• pubmed:25505847
• pubmed:25520806
• pubmed:25782916
• pubmed:26750740
• pubmed:27095947
• pubmed:27271328
• pubmed:28915585
• pubmed:32534122
• pubmed:33500709
• pubmed:34696786
• pubmed:38378603
• wikipedia.en:Abexinostat

Ontology

ChEBI  ( EBI )