CHIR-265

Term ID

CHEBI:91451

Synonyms

1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
CHIR 265
CHIR265
RAF 265
RAF-265
RAF265

(all 6)

Definition

A member of the class of benzimidazoles that is 1H-benzimidazole substituted by methyl, [4-(trifluoromethyl)phenyl]amino, and {2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy groups at positions 1, 2, and 5, respectively. It is an inhibitor of RAF kinases, including the BRAF V600E mutant.

References

(all 26)

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: (trifluoromethyl)benzenes aromatic ether benzimidazoles imidazoles organofluorine compound ... Show All 7 Terms

(trifluoromethyl)benzenes aromatic ether benzimidazoles imidazoles organofluorine compound pyridines substituted aniline Show first 5 Terms
has_role: angiogenesis inhibitor antineoplastic agent antiviral agent apoptosis inducer B-Raf inhibitor ... Show All 6 Terms

angiogenesis inhibitor antineoplastic agent antiviral agent apoptosis inducer B-Raf inhibitor EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from CHIR-265

Phenotype where environments contain CHIR-265

Phenotype modified by environments containing CHIR-265

Phenotype affecting CHIR-265

Human Disease Model