momelotinib

Term ID

CHEBI:91407

Synonyms

CYT 11387
CYT 387
CYT-11387
CYT-387
CYT387
GS-0387
LM-1149
momelotinib
momelotinibum
N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide
N-(cyanomethyl)-4-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)benzamide
N-(cyanomethyl)-4-(2-((4-morpholinophenyl)-amino)pyrimidin-4-yl)benzamide
N-(cyanomethyl)-4-[2-[4-(4-morpholinyl)anilino]-4-pyrimidinyl]benzamide
N-(cyanomethyl)-4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzamide
Ojjaara

Definition

A benzamide obtained by formal condensation of the carboxy group of 4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzoic acid with the primary amino group of aminoacetonitrile. It is an ATP-competitive JAK1/JAK2 inhibitor with IC₅₀ of 11 nM and 18 nM, respectively. Used for the treatment of patients with intermediate- or high-risk myelofibrosis.

References

cas:1056634-68-4
drugbank:DB11763
kegg.drug:D10315
lincs.smallmolecule:LSM-1141
pdb-ccd:C87
pmc:PMC10431522
pubmed:19762238
pubmed:21079613
pubmed:23459451
pubmed:25322686
pubmed:25511866
pubmed:27634203
pubmed:27785927
pubmed:28622623
pubmed:28930494
pubmed:28960447
pubmed:29024542
pubmed:29263442
pubmed:29275119
pubmed:29283448
pubmed:29311136
pubmed:29515114
pubmed:30087028
pubmed:30105668
pubmed:31450973
pubmed:31560729
pubmed:32394008
pubmed:34704880
pubmed:34768286
pubmed:35045875
pubmed:35255234
pubmed:35345816
pubmed:35413417
pubmed:35603634
pubmed:35869266
pubmed:36349465
pubmed:36599841
pubmed:36709073
pubmed:36861402
pubmed:37021939
pubmed:37039727
pubmed:37042865
pubmed:37517413
pubmed:37901848
pubmed:37908862
pubmed:37989928
pubmed:38164985
pubmed:38201581
pubmed:38311180
pubmed:38406514
pubmed:38501751
wikipedia.en:Momelotinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from momelotinib

Phenotype where environments contain momelotinib

Phenotype modified by environments containing momelotinib

Phenotype affecting momelotinib

Human Disease Model