salsalate

Term ID

CHEBI:9014

Synonyms

2-[(2-hydroxybenzoyl)oxy]benzoic acid
2-Carboxyphenyl salicylate
Disalcid
Disalicylic acid
Disalicylsaeure
O-Salicylcylsalicylsaeure
o-Salicylsalicylic acid
Salicylic acid bimolecular ester
Salicyloxysalicylic acid
Salicyloylsalicylic acid
salicylsalicylic acid
salsalate
salsalato
salsalatum
Sasapyrin
Sasapyrine
Sasapyrinum

Definition

A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.

References

cas:552-94-3
drugbank:DB01399
drugcentral:2420
kegg.drug:D00428
pubmed:19747808
pubmed:20613460
pubmed:20876710
pubmed:21289240
pubmed:21519323
pubmed:21617098
pubmed:21764223
pubmed:21903749
pubmed:21938543
pubmed:22357964
pubmed:22388922
pubmed:22517326
pubmed:22782506
pubmed:22784842
pubmed:23370525
pubmed:23680037
pubmed:23801715
pubmed:23817699
pubmed:23817718
pubmed:23825542
pubmed:23871515
pubmed:23948064
pubmed:24130358
pubmed:28166217
reaxys:2590908
wikipedia.en:Salsalate

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from salsalate

Phenotype where environments contain salsalate

Phenotype modified by environments containing salsalate

Phenotype affecting salsalate

Human Disease Model