rofecoxib

Term ID

CHEBI:8887

Synonyms

• 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
• 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
• 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
• Ceoxx
• rofecoxib
• rofecoxibum
• Vioxx

Definition

A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.

References

• cas:162011-90-7
• drugbank:DB00533
• drugcentral:2397
• kegg.compound:C07590
• kegg.drug:D00568
• lincs.smallmolecule:LSM-2482
• pubmed:10859630
• pubmed:11014111
• pubmed:12069696
• pubmed:16934051
• pubmed:20162413
• pubmed:28166217
• reaxys:8269007
• wikipedia.en:Rofecoxib

Ontology

ChEBI  ( EBI )