mycophenolate mofetil

Term ID

CHEBI:8764

Synonyms

2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
Cellcept
MMF
mycophenolic acid morpholinoethyl ester
RS 61443

(all 6)

Definition

A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.

References

(all 24)

Ontology

ChEBI ( EBI )

Relationships

is a type of: carboxylic ester ether gamma-lactone phenols tertiary amino compound

carboxylic ester ether gamma-lactone phenols tertiary amino compound Show first 5 Terms
has_functional_parent: 2-(morpholin-4-yl)ethanol mycophenolic acid

2-(morpholin-4-yl)ethanol mycophenolic acid Show first 5 Terms
has_role: anticoronaviral agent EC 1.1.1.205 (IMP dehydrogenase) inhibitor immunosuppressive agent prodrug

anticoronaviral agent EC 1.1.1.205 (IMP dehydrogenase) inhibitor immunosuppressive agent prodrug Show first 5 Terms

Phenotype

Phenotype resulting from mycophenolate mofetil

Phenotype where environments contain mycophenolate mofetil

Phenotype modified by environments containing mycophenolate mofetil

Phenotype affecting mycophenolate mofetil

Human Disease Model