Search Ontology:
ChEBI
LY-411575
- Term ID
- CHEBI:87359
- Synonyms
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- LSN-411575
- LY-411575
- LY411575
- N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
- N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N(1)-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
- Definition
- A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.
- References
-
- CAS:209984-57-6
- PMID:14718585
- PMID:15743924
- PMID:17897827
- PMID:19419556
- PMID:22824752
- PMID:23209290
- PMID:23312516
- PMID:23901284
- PMID:24113577
- PMID:24223998
- PMID:24884926
- PMID:25781991
- Reaxys:10736555
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
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Phenotype
Phenotype resulting from LY-411575
Phenotype where environments contain LY-411575
Phenotype modified by environments containing LY-411575
Human Disease Model