LY-411575

Term ID

CHEBI:87359

Synonyms

• LSN-411575
• LY-411575
• LY411575
• N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
• N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N(1)-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide

Definition

A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N²-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective γ-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.

References

• pubmed:14718585
• pubmed:15743924
• pubmed:17897827
• pubmed:19419556
• pubmed:22824752
• pubmed:23209290
• pubmed:23312516
• pubmed:23901284
• pubmed:24113577
• pubmed:24223998
• pubmed:24884926
• pubmed:25781991
• reaxys:10736555

Ontology

ChEBI  ( EBI )