4beta-hydroxycholesterol

Term ID

CHEBI:85778

Synonyms

(3beta,4beta)-cholest-5-ene-3,4-diol
4-beta-hydroxycholesterol
cholest-5-en-3beta,4beta-diol
cholest-5-ene-3beta,4beta-diol

Definition

A oxysterol that is cholesterol in which the hydrogen at the 4β position has been replaced by a hydroxy group. A metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P450 3A4, it is one of the major oxysterols in the human circulation.

References

cas:17320-10-4
hmdb:HMDB0013643
lipidmaps:LMST01010014
pubmed:11514559
pubmed:12077124
pubmed:18279471
pubmed:18300941
pubmed:19006545
pubmed:19458613
pubmed:21728364
pubmed:8656065

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from 4beta-hydroxycholesterol

Phenotype where environments contain 4beta-hydroxycholesterol

Phenotype modified by environments containing 4beta-hydroxycholesterol

Phenotype affecting 4beta-hydroxycholesterol

Human Disease Model