netupitant

Term ID

CHEBI:85155

Synonyms

• 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
• netupitant

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid with the secondary amino group of N-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-amine; an antiemetic used in combination with palonosetron hydrochloride (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.

References

• cas:290297-26-6
• drugcentral:4898
• kegg.drug:D05152
• pubmed:22732666
• pubmed:23729226
• pubmed:23748441
• pubmed:23765630
• pubmed:24122871
• pubmed:24468892
• pubmed:24603643
• pubmed:24608196
• pubmed:24631949
• pubmed:24942276
• pubmed:24969614
• pubmed:25077526
• pubmed:25105088
• pubmed:25227565
• pubmed:25360998
• pubmed:25404586
• pubmed:25552904
• pubmed:25687374
• reaxys:10314678

Ontology

ChEBI  ( EBI )