ponatinib

Term ID

CHEBI:78543

Synonyms

3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
AP 24534
AP-24534
AP24534
ponatinib
ponatinibum

Definition

A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABL^T315I.

References

cas:943319-70-8
drugbank:DB08901
drugcentral:4716
hmdb:HMDB0240214
kegg.drug:D09950
lincs.smallmolecule:LSM-1151
patent:US2014038920
pmc:PMC8895737
pubmed:24297701
pubmed:24402926
pubmed:24407160
pubmed:24408322
pubmed:24472312
pubmed:24481648
pubmed:24550512
pubmed:24552773
pubmed:24586514
pubmed:24596204
pubmed:24602068
pubmed:24695735
pubmed:24729118
pubmed:24756787
pubmed:24766374
pubmed:24768818
pubmed:24807266
pubmed:24934866
pubmed:30417093
pubmed:33929369
pubmed:34406581
pubmed:34649276
pubmed:34821935
pubmed:34871094
pubmed:34885009
pubmed:34939982
pubmed:34984405
pubmed:34987886
pubmed:35059859
pubmed:35091442
pubmed:35091541
pubmed:35122387
pubmed:35151199
pubmed:35325305
pubmed:35332794
pubmed:35338182
pubmed:35349077
pubmed:35411096
pubmed:35412404
pubmed:35544670
reaxys:12923700
wikipedia.en:Ponatinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from ponatinib

Phenotype where environments contain ponatinib

Phenotype modified by environments containing ponatinib

Phenotype affecting ponatinib

Human Disease Model