Search Ontology:
ChEBI
proglumetacin
- Term ID
- CHEBI:76263
- Synonyms
-
- 3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate
- proglumetacin
- proglumetacina
- proglumetacine
- proglumetacinum
- Definition
- A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropyl-α-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.
- References
-
- cas:57132-53-3
- drugcentral:2280
- kegg.drug:D08427
- patent:US6599529
- pubmed:1626095
- pubmed:1778279
- pubmed:2491526
- pubmed:2653004
- pubmed:2974384
- pubmed:3663267
- pubmed:3860726
- pubmed:3887221
- pubmed:3905222
- pubmed:4074450
- pubmed:6222270
- pubmed:6222271
- pubmed:6343924
- pubmed:6381269
- pubmed:6602308
- pubmed:6602309
- pubmed:6602310
- pubmed:6728264
- pubmed:6728268
- pubmed:6856162
- pubmed:6856163
- pubmed:6856164
- pubmed:6856165
- pubmed:6856166
- pubmed:6856167
- reaxys:876871
- wikipedia.en:Proglumetacin
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from proglumetacin
Phenotype where environments contain proglumetacin
Phenotype modified by environments containing proglumetacin
Phenotype affecting proglumetacin
Human Disease Model