proglumetacin

Term ID

CHEBI:76263

Synonyms

3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate
proglumetacin
proglumetacina
proglumetacine
proglumetacinum

(all 5)

Definition

A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.

References

(all 31)

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aromatic ether benzamides carboxylic ester monochlorobenzenes N-acylindole ... Show All 6 Terms

aromatic ether benzamides carboxylic ester monochlorobenzenes N-acylindole N-alkylpiperazine Show first 5 Terms
has_functional_parent: indometacin proglumide

indometacin proglumide Show first 5 Terms
has_role: antipyretic EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor lipoxygenase inhibitor non-narcotic analgesic non-steroidal anti-inflammatory drug ... Show All 6 Terms

antipyretic EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor lipoxygenase inhibitor non-narcotic analgesic non-steroidal anti-inflammatory drug prodrug Show first 5 Terms
inverse has_part: proglumetacin dimaleate

proglumetacin dimaleate Show first 5 Terms

Phenotype

Phenotype resulting from proglumetacin

Phenotype where environments contain proglumetacin

Phenotype modified by environments containing proglumetacin

Phenotype affecting proglumetacin

Human Disease Model