indoprofen

Term ID

CHEBI:76162

Synonyms

1-Oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline
2-(4-(1-Carboxyethyl)phenyl)-1-isoindolinone
2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid
alpha-(4-(1-Oxo-2-isoindolinyl)phenyl)propionic acid
indoprofen
indoprofene
indoprofeno
indoprofenum
K 4277

Definition

A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.

References

cas:31842-01-0
drugcentral:1442
kegg.drug:D04530
lincs.smallmolecule:LSM-1564
patent:NZ586198
patent:WO2008011083
pubmed:1017174
pubmed:22282415
pubmed:22349325
pubmed:2519164
pubmed:2753348
pubmed:2775332
pubmed:369767
pubmed:378745
pubmed:392647
pubmed:47280
pubmed:550151
pubmed:6436749
pubmed:6578800
pubmed:7042369
pubmed:7341277
pubmed:7349186
pubmed:7428321
reaxys:1543920
wikipedia.en:Indoprofen

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from indoprofen

Phenotype where environments contain indoprofen

Phenotype modified by environments containing indoprofen

Phenotype affecting indoprofen

Human Disease Model