dolutegravir

Term ID

CHEBI:76010

Synonyms

(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
S/GSK1349572

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1.

References

cas:1051375-16-6
drugcentral:4805
kegg.drug:D10066
patent:EP2602260
patent:WO2006116764
pdb-ccd:DLU
pubmed:22018760
pubmed:22205735
pubmed:22878423
pubmed:22905856
pubmed:23075918
pubmed:23132334
pubmed:23225901
pubmed:23295935
pubmed:23306000
pubmed:23413040
pubmed:23432922
pubmed:23455469
pubmed:23669385
pubmed:23777012
pubmed:23798668
pubmed:23807273
pubmed:23817375
pubmed:23824675
pubmed:23830355
pubmed:23845180
pubmed:23885999
pubmed:23942060
pubmed:24052331
pubmed:24074642
pubmed:24096683
reaxys:12732602
wikipedia.en:Dolutegravir

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from dolutegravir

Phenotype where environments contain dolutegravir

Phenotype modified by environments containing dolutegravir

Phenotype affecting dolutegravir

Human Disease Model