platensimycin

Term ID

CHEBI:68236

Synonyms

• (-)-platensimycin
• 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-1,2,5,6,7,8,9,9a-octahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid
• 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-Hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxybenzoic acid

Definition

A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the oxatetracyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.

References

• cas:835876-32-9
• chemspider:5257055
• drugbank:DB08407
• kegg.compound:C20132
• knapsack:C00048823
• patent:CA2770486
• patent:US2009081673
• pdb-ccd:PMN
• pubmed:16710421
• pubmed:19581087
• pubmed:20158476
• pubmed:21214253
• pubmed:21808805
• pubmed:21915133
• pubmed:23373732
• pubmed:27126098
• pubmed:27695056
• pubmed:30216060
• pubmed:30461269
• pubmed:30735041
• pubmed:30816397
• pubmed:31265289
• pubmed:31291107
• pubmed:32232122
• pubmed:32519867
• pubmed:34189850
• reaxys:10740321
• wikipedia.en:Platensimycin

Ontology

ChEBI  ( EBI )