ingenol mebutate

Term ID

CHEBI:66913

Synonyms

• (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[E][10]annulen-6-yl (2Z)-2-methylbut-2-enoate
• 3-Angeloylingenol
• 3-Ingenyl angelate
• Ingenol 3-angelate
• ingenol mebutate
• ingenoli mebutas
• mebutate d'ingenol
• mebutato de ingenol
• PEP-005
• Picato

Definition

A tetracyclic diterpenoid ester obtained by formal condensation of the carboxy group of (2Z)-2-methylbut-2-enoic (angelic) acid with the 3-hydroxy group of ingenol. Used for the topical treatment of actinic keratosis.

References

• cas:75567-37-2
• kegg.drug:D09393
• pubmed:19178487
• pubmed:19467365
• pubmed:20546215
• pubmed:20725548
• pubmed:21325841
• pubmed:21375515
• pubmed:21386954
• pubmed:22055282
• pubmed:22189786
• pubmed:22202647
• pubmed:22358305
• pubmed:22417254
• pubmed:22538622
• pubmed:22618984
• pubmed:22828167
• pubmed:22956883
• reaxys:6452385
• wikipedia.en:Ingenol_mebutate

Ontology

ChEBI  ( EBI )