rotundifolioside J

Term ID

CHEBI:66317

Synonyms

(3beta,16alpha)-16-hydroxy-13,28-epoxyurs-11-en-3-yl 6-deoxy-alpha-L-mannopyranosyl-(1->2)-beta-D-glucopyranosyl-(1->2)-6-deoxy-beta-D-galactopyranoside
13beta,28-epoxy-16alpha-hydroxyurs-11-en-3beta-yl alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl-(1->2)-beta-D-fucopyranoside

Definition

A triterpenoid saponin that consists of urs-11-ene substituted by an epoxy group across positions 13 and 28, a hydroxy group at position 16 and a alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl-(1->2)-beta-D-fucopyranosyloxy residue at position 3 (the 3beta,16alpha stereoisomer). Isolated from the fruits of Bupleurum rotundifolium, it exhibits antiproliferative activity against cancer cells.

References

PMID:12672986
Reaxys:9468714

Ontology

ChEBI ( EBI )

Relationships

is a type of: bridged compound cyclic ether hexacyclic triterpenoid trisaccharide derivative triterpenoid saponin

bridged compound cyclic ether hexacyclic triterpenoid trisaccharide derivative triterpenoid saponin Show first 5 Terms
has_parent_hydride: ursane

ursane Show first 5 Terms
has_role: antineoplastic agent plant metabolite

antineoplastic agent plant metabolite Show first 5 Terms

Phenotype

Phenotype resulting from rotundifolioside J

Phenotype where environments contain rotundifolioside J

Phenotype modified by environments containing rotundifolioside J

Human Disease Model