crizotinib

Term ID

CHEBI:64310

Synonyms

(R)-crizotinib
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
crizotinib
crizotinibum
PF 2341066
PF-2341066

(all 6)

Definition

A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)

References

(all 29)

Ontology

ChEBI ( EBI )

Relationships

is a type of: 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine Show first 5 Terms
has_role: antineoplastic agent biomarker EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor

antineoplastic agent biomarker EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor Show first 5 Terms
inverse has_part: rac-crizotinib

rac-crizotinib Show first 5 Terms
inverse is_enantiomer_of: ent-crizotinib

ent-crizotinib Show first 5 Terms
is_enantiomer_of: ent-crizotinib

ent-crizotinib Show first 5 Terms

Phenotype

Phenotype resulting from crizotinib

Phenotype where environments contain crizotinib

Phenotype modified by environments containing crizotinib

Phenotype affecting crizotinib

Human Disease Model