GR 127935 hydrochloride

Term ID

CHEBI:64111

Synonyms

4-[2-methoxy-5-({[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl}amino)phenyl]-1-methylpiperazin-1-ium chloride
GR127935 hydrochloride
N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide hydrochloride

Definition

A hydrochloride obtained by reaction of GR 127935 with one equivalent of hydrochloric acid. Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration.

References

Reaxys:8530522

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrochloride

hydrochloride Show first 5 Terms
has_part: GR 127935(1+)

GR 127935(1+) Show first 5 Terms
has_role: serotonergic antagonist

serotonergic antagonist Show first 5 Terms

Phenotype

Phenotype resulting from GR 127935 hydrochloride

Phenotype where environments contain GR 127935 hydrochloride

Phenotype modified by environments containing GR 127935 hydrochloride

Phenotype affecting GR 127935 hydrochloride

Human Disease Model