Search Ontology:
ChEBI

1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine

Term ID
CHEBI:64093
Synonyms
  • 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine
  • GBR 12935
  • GBR12935
Definition
An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
References
  • cas:76778-22-8
  • lincs.smallmolecule:LSM-3101
  • pubmed:1346964
  • pubmed:18596684
  • pubmed:18784647
  • pubmed:19924693
  • pubmed:20576034
  • pubmed:21693154
  • pubmed:21741457
  • pubmed:21990355
  • pubmed:2952763
  • pubmed:3436357
  • pubmed:8007761
  • pubmed:9286626
  • reaxys:578614
  • wikipedia.en:GBR-12935
Ontology
ChEBI  ( EBI )
Relationships
Phenotype
Phenotype resulting from 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine
Phenotype where environments contain 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine
Phenotype modified by environments containing 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine
Phenotype affecting 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine
Human Disease Model