4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline

Term ID

CHEBI:64055

Synonyms

4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline
CGS 12066B

Definition

A pyrroloquinoxaline that is pyrrolo[1,2-a]quinoxaline bearing additional 4-methylpiperazin-1-yl and trifluoromethyl substituents at positions 4 and 7 respectively. A 5-hydroxytryptamine receptor 1B (5-HT_1B) full agonist, 10-fold selective over 5-HT_1A and 1000-fold selective over 5-HT_2C receptors. Centrally active following systemic administration.

References

lincs.smallmolecule:LSM-2420
pubmed:10607113
pubmed:11224163
pubmed:11224442
pubmed:1362158
pubmed:1645675
pubmed:17392733
pubmed:2255331
pubmed:3496228
pubmed:7501681
pubmed:8223931
reaxys:4206934

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline

Phenotype where environments contain 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline

Phenotype modified by environments containing 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline

Phenotype affecting 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline

Human Disease Model