lamivudine

Term ID

CHEBI:63577

Synonyms

(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
(-)-2'-Deoxy-3'-thiacytidine
2',3'-Dideoxy-3'-thiacytidine
3'-Thia-2',3'-dideoxycytidine
3TC
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
beta-L-2',3'-Dideoxy-3'-thiacytidine
beta-L-3'-Thia-2',3'-dideoxycytidine
Epivir
Lamivudine

(all 10)

Definition

A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase, it is used as an antiviral in the treatment of AIDS and hepatitis B.

References

(all 30)

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: monothioacetal nucleoside analogue oxacycle primary alcohol

monothioacetal nucleoside analogue oxacycle primary alcohol Show first 5 Terms
has_functional_parent: cytosine

cytosine Show first 5 Terms
has_role: allergen anti-HBV agent antiviral drug EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor HIV-1 reverse transcriptase inhibitor ... Show All 6 Terms

allergen anti-HBV agent antiviral drug EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor HIV-1 reverse transcriptase inhibitor prodrug Show first 5 Terms

Phenotype

Phenotype resulting from lamivudine

Phenotype where environments contain lamivudine

Phenotype modified by environments containing lamivudine

Phenotype affecting lamivudine

Human Disease Model