mercaptopurine

Term ID

CHEBI:50667

Synonyms

• 1,7-dihydro-6H-purine-6-thione
• 6 MP
• 6-Mercaptopurine
• 6-MP
• 6-Thiohypoxanthine
• 6-Thioxopurine
• Mercaptopurina
• mercaptopurine
• mercaptopurinum
• Mercapurin
• Puri-Nethol
• Purinethol

Definition

A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.

References

• cas:50-44-2
• drugbank:DB01033
• kegg.compound:C02380
• kegg.drug:D04931
• patent:US2697709
• patent:US2721866
• pdb-ccd:PM6
• pubmed:16267626
• pubmed:28011186
• pubmed:28166217
• pubmed:28212467
• pubmed:28295989
• pubmed:28301625
• pubmed:28406092
• pubmed:28418010
• pubmed:28484608
• pubmed:28574837
• reaxys:132916

Ontology

ChEBI  ( EBI )