vandetanib

Term ID

CHEBI:49960

Synonyms

4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
vandetanib
Zactima
ZD 6474
ZD6474

Definition

A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.

References

cas:443913-73-3
drugbank:DB08764
drugcentral:4178
kegg.drug:D06407
lincs.smallmolecule:LSM-1199
patent:US2006135486
patent:US2008032989
patent:US2008199480
patent:WO2005115145
patent:WO2006005915
patent:WO2007036713
patent:WO2008001101
patent:WO2008007113
patent:WO2009024825
patent:WO2012055015
pdb-ccd:ZD6
pubmed:12684431
pubmed:14760102
pubmed:15305185
pubmed:15367698
pubmed:15596048
pubmed:15604279
pubmed:15623642
pubmed:15623658
pubmed:15928657
pubmed:16140331
pubmed:16179094
pubmed:16299247
pubmed:16361567
pubmed:16377413
pubmed:16688779
pubmed:16783964
pubmed:16843002
pubmed:17136225
pubmed:17393165
pubmed:17409986
pubmed:17631646
pubmed:17878479
pubmed:17912240
pubmed:18228115
pubmed:18698025
pubmed:18936474
pubmed:19002384
pubmed:19088171
pubmed:19211364
pubmed:19220256
pubmed:19332730
pubmed:19349511
pubmed:19394692
pubmed:19512898
pubmed:19622715
pubmed:19687425
pubmed:19881951
pubmed:19883226
pubmed:19946413
pubmed:20371720
pubmed:21046425
pubmed:21353546
pubmed:21718364
pubmed:22075979
pubmed:22158569
pubmed:22169262
pubmed:22184381
pubmed:22245891
pubmed:22307735
pubmed:22343387
pubmed:22346266
pubmed:22370318
pubmed:22500115
pubmed:22505191
pubmed:22608542
pubmed:22611027
pubmed:22633931
pubmed:22665903
pubmed:22667325
pubmed:22701615
pubmed:22781612
pubmed:22830347
pubmed:22898678
pubmed:22938056
reaxys:9161676
wikipedia.en:Vandetanib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from vandetanib

Phenotype where environments contain vandetanib

Phenotype modified by environments containing vandetanib

Phenotype affecting vandetanib

Human Disease Model