BI-2536

Term ID

CHEBI:49868

Synonyms

(R)-4-[(8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
BI 2536
BI2536

Definition

A member of the class of tetrahydropterins that is 7,8-dihydropteridin-6(5H)-one substituted by {2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino, methyl, ethyl, and cyclopentyl groups at positions 2, 5, 7R, and 8, respectively. It is a polo-like kinase 1 (PLK1) inhibitor with antineoplastic activity.

References

cas:755038-02-9
drugbank:DB16107
lincs.smallmolecule:LSM-1041
pdb-ccd:R78
pubmed:17291761
pubmed:20886032
pubmed:21415595
pubmed:22080235
pubmed:22527426
pubmed:22745587
pubmed:23962445
pubmed:24519995
pubmed:25565629
pubmed:26191363
pubmed:28212994
pubmed:28531794
pubmed:28927329
pubmed:29476067
pubmed:31620231
pubmed:32231733
pubmed:33067313
pubmed:33222770
pubmed:35056094
pubmed:35644070
pubmed:36016611
pubmed:36054794
pubmed:36178637
pubmed:37477142
pubmed:37850387
pubmed:38072041
pubmed:38536443
pubmed:38691920

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from BI-2536

Phenotype where environments contain BI-2536

Phenotype modified by environments containing BI-2536

Phenotype affecting BI-2536

Human Disease Model