ABT-737

Term ID

CHEBI:47575

Synonyms

• 4-{4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]piperazin-1-yl}-N-(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene-1-sulfonyl)benzamide
• 4-{4-[(4'-chloro[biphenyl]-2-yl)methyl]piperazin-1-yl}-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]benzamide
• ABT 737
• ABT737

Definition

A biphenyl that is 4-chloro-1,1'-biphenyl substituted by a (4-{4-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene-1-sulfonyl)carbamoyl]phenyl}piperazin-1-yl)methyl group at position 2'. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells.

References

• cas:852808-04-9
• chemspider:9403232
• lincs.smallmolecule:LSM-1180
• pdb-ccd:N3C
• pubmed:17572662
• pubmed:26880588
• pubmed:29543705
• pubmed:29792865
• pubmed:29856968
• pubmed:30389373
• pubmed:30402442
• pubmed:30557204
• pubmed:30625226
• pubmed:30721730
• pubmed:31493778
• pubmed:31579427
• pubmed:31612056
• pubmed:31906234
• pubmed:32079453
• pubmed:32083466
• pubmed:32139422
• pubmed:32212793
• pubmed:32424251
• pubmed:32470451
• pubmed:32580291
• pubmed:32623836
• pubmed:32811502
• pubmed:32966375
• pubmed:33140666
• pubmed:33218059
• pubmed:33396645
• pubmed:33523649
• pubmed:33786632
• pubmed:33787344
• wikipedia.en:ABT-737

Ontology

ChEBI  ( EBI )