Search Ontology:
ChEBI

(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

Term ID
CHEBI:45302
Synonyms
  • (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
  • 5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione
  • 5-[(quinoxalin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
  • 5-quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
  • 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione
  • AS 605240
  • AS-605240
  • AS605240
(all 8)
Definition
A quinoxaline derivative that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis.
References
(all 18)
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Phenotype where environments contain (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Phenotype modified by environments containing (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Phenotype affecting (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Human Disease Model
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.