AEE788

Term ID

CHEBI:40629

Synonyms

6-{4-[(4-ethyl-1-piperazinyl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-1H-pyrrolo[2,3-d]pyrimidin-4-amine
6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
[6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-((R)-1-phenylethyl)amine
AEE 788
AEE-788
NVP-AEE-788
NVP-AEE788

(all 7)

Definition

A 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which adopts an R-configuration. It is a potent inhibitor of human EGFR, VEGFR and HER2 receptor tyrosine kinases and exhibits anticancer and antiangiogenic activity.

References

(all 39)

Ontology

ChEBI ( EBI )

Relationships

is a type of: 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Show first 5 Terms
has_role: angiogenesis inhibitor antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor epidermal growth factor receptor antagonist ... Show All 6 Terms

angiogenesis inhibitor antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor epidermal growth factor receptor antagonist trypanocidal drug Show first 5 Terms

Phenotype

Phenotype resulting from AEE788

Phenotype where environments contain AEE788

Phenotype modified by environments containing AEE788

Phenotype affecting AEE788

Human Disease Model