Search Ontology:
ChEBI
D-cycloserine
- Term ID
- CHEBI:40009
- Synonyms
-
- (+)-4-amino-3-isoxazolidinone
- (+)-cycloserine
- (4R)-4-aminoisoxazolidin-3-one
- Definition
- A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).
- References
-
- CAS:68-41-7
- DrugBank:DB00260
- Drug_Central:759
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
-
- has_role
-
- inverse has_part
-
- inverse is_conjugate_acid_of
-
- inverse is_enantiomer_of
-
- inverse is_tautomer_of
-
- is_conjugate_base_of
-
- is_enantiomer_of
-
- is_tautomer_of
-
Show first 5 Terms
Phenotype
Phenotype resulting from D-cycloserine
No data available
Phenotype where environments contain D-cycloserine
| Fish | Conditions | Phenotype | Term | Figures |
|---|---|---|---|---|
| chd7ck004a/+ | chemical treatment by environment: D-cycloserine | Fig. 2 from Liu et al., 2019 |
1 - 1 of 1
Show
Phenotype modified by environments containing D-cycloserine
Phenotype affecting D-cycloserine
Human Disease Model