idebenone

Term ID

CHEBI:31687

Synonyms

• 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone
• 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone
• 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone
• 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
• 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone
• 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinone
• CV 2619
• CV-2619
• idebenona
• idebenone
• idebenonum
• Raxone

Definition

A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.

References

• cas:58186-27-9
• chemspider:3558
• drugbank:DB09081
• drugcentral:1416
• kegg.drug:D01750
• lincs.smallmolecule:LSM-5505
• patent:DE2519730
• patent:US4271083
• pubmed:11207459
• pubmed:15374364
• pubmed:18045357
• pubmed:18710357
• pubmed:19283347
• pubmed:19283350
• pubmed:20955109
• pubmed:22269948
• pubmed:23859348
• pubmed:2669658
• pubmed:30726629
• pubmed:32111141
• pubmed:33247801
• pubmed:33254077
• pubmed:33628024
• pubmed:7981485
• pubmed:7988944
• reaxys:2001459
• wikipedia.en:Idebenone

Ontology

ChEBI  ( EBI )

Resources

CTD