chlorambucil

Term ID

CHEBI:28830

Synonyms

• 4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid
• 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid
• 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid
• Ambochlorin
• CHLORAMBUCIL
• chloraminophen
• gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid
• Leukeran
• N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid
• phenylbutyric acid nitrogen mustard

Definition

A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

References

• cas:305-03-3
• drugbank:DB00291
• drugcentral:588
• kegg.drug:D00266
• lincs.smallmolecule:LSM-2645
• pdb-ccd:CBL
• pubmed:22025197
• pubmed:22978684
• pubmed:23233721
• pubmed:23295789
• pubmed:23521128
• pubmed:23665800
• pubmed:23667729
• pubmed:23683018
• pubmed:23725434
• pubmed:23822827
• pubmed:24098639
• pubmed:24147900
• pubmed:24223689
• reaxys:999011
• wikipedia.en:Chlorambucil

Ontology

ChEBI  ( EBI )

Resources

CTD