Search Ontology:
ChEBI
Pac-1
- Term ID
- CHEBI:231696
- Synonyms
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- PAC 1
- PAC1
- Procaspase activating compound 1
- Procaspase-3 Activator
- Definition
- Procaspase Activating Compound-1 VO-100 is an orally bioavailable procaspase activating compound-1 (PAC-1), with potential proapoptotic and antineoplastic activities. Upon administration, VO-100 binds to and forms a chelating complex with zinc (Zn) ions inside cells, which prevents the binding of Zn ions to procaspase-3 (PC3) and abrogates the Zn-mediated inhibition of PC3. This allows for the proteolytic autoactivation of PC3 into the active form caspase-3. This results in the selective caspase-3-mediated induction of apoptosis and cell death in cancer cells. In addition, VO-100 is able to cross the blood-brain-barrier (BBB). PC3, a Zn-inhibited proenzyme, is upregulated in a variety of cancer cell types, while its expression is minimal in normal healthy cells.
- References
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- cas:315183-21-2
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from Pac-1
Phenotype where environments contain Pac-1
Phenotype modified by environments containing Pac-1
Phenotype affecting Pac-1
Human Disease Model