Search Ontology:
ChEBI
SCH529074
- Term ID
- CHEBI:231690
- Synonyms
-
- N'-(2-{4-[bis-(4-chlorophenyl)methyl]piperazin-1-ylmethyl}quinazolin-4-yl)-N,N-dimethylpropane-1,3-diamine
- SCH 529074
- SCH-529074
- Definition
- SCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a Ki of 1-2 uM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC). (MedChemExpress)
- References
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from SCH529074
Phenotype where environments contain SCH529074
Phenotype modified by environments containing SCH529074
Phenotype affecting SCH529074
Human Disease Model