evofosfamide

Term ID

CHEBI:231678

Synonyms

(1-methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine
evofosfamida
evofosfamide
evofosfamidum
HAP-302
TH 302
TH-302
TH302

(all 9)

Definition

A member of the class of imidazoles that is 1H-imidazole substituted by methyl, nitro, and ({bis[(2-bromoethyl)amino]phosphoryl}oxy)methyl groups at positions 1, 2 and 5, respectively. It is a hypoxia-activated prodrug that targets hypoxic regions of tumors. The drug was being evaluated for first-line treatment of advanced pancreatic adenocarcinoma and advanced soft tissue sarcoma, in combination with chemotherapy (phase 3 trial now discontinued since the drug did not meet primary endpoints).

References

(all 45)

Ontology

ChEBI ( EBI )

Relationships

is a type of: C-nitro compound imidazoles organobromine compound phosphorodiamidate ester tertiary amino compound

C-nitro compound imidazoles organobromine compound phosphorodiamidate ester tertiary amino compound Show first 5 Terms
has_role: alkylating agent antineoplastic agent prodrug

alkylating agent antineoplastic agent prodrug Show first 5 Terms

Phenotype

Phenotype resulting from evofosfamide

Phenotype where environments contain evofosfamide

Phenotype modified by environments containing evofosfamide

Phenotype affecting evofosfamide

Human Disease Model