Search Ontology:
ChEBI
vosaroxin
- Term ID
- CHEBI:231651
- Synonyms
-
- (+)-1,4-dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
- 7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
- AG 7352
- AG-7352
- AG7352
- SNS 595
- SNS-595
- SPC-595
- voreloxin
- vosaroxin
- vosaroxina
- vosaroxine
- vosaroxinum
- Definition
- A 1,8-naphthyridine derivative that is 1,8-naphthyridin-4(1H)-one substituted by 1,3-thiazol-2-yl, carboxy, and (3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl groups at positions 1, 3, and 7, respectively. It targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to apoptosis in cancer cells.
- References
-
- cas:175414-77-4
- drugbank:DB11999
- kegg.drug:D08024
- patent:US2011312988
- pubmed:15056007
- pubmed:18931998
- pubmed:19074528
- pubmed:20419121
- pubmed:22369205
- pubmed:22724917
- pubmed:23688047
- pubmed:25381131
- pubmed:25403830
- pubmed:25534904
- pubmed:25805811
- pubmed:25958926
- pubmed:26234173
- pubmed:27158854
- pubmed:27236532
- pubmed:27484675
- pubmed:27615555
- pubmed:28138829
- pubmed:28415741
- pubmed:28504025
- pubmed:28567238
- pubmed:28729302
- pubmed:28860803
- pubmed:29794146
- pubmed:29800573
- pubmed:30396931
- pubmed:31115744
- pubmed:31482470
- wikipedia.en:Vosaroxin
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from vosaroxin
Phenotype where environments contain vosaroxin
Phenotype modified by environments containing vosaroxin
Phenotype affecting vosaroxin
Human Disease Model