varlitinib

Term ID

CHEBI:231356

Synonyms

• AR-00334543
• AR00334543
• ARRY 334543
• ARRY-334543
• ARRY-543
• ASLAN-001
• ASLAN001
• N(4)-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-N(6)-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine
• varlitinib
• varlitinibum

Definition

A member of the class of quinazolines that is quinazoline substituted by {3-chloro-4-[(1,3-thiazol-2-yl)methoxy]phenyl}amino and [(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]amino groups at positions 4 and 6, respectively. It is a tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR and has shown significant anti-tumour activity in preclinical models of human breast, lung, and epidermal carcinoma tumours.

References

• cas:845272-21-1
• drugbank:DB05944
• kegg.drug:D09689
• pmc:PMC6421168
• pmc:PMC6421180
• pmc:PMC6421189
• pubmed:24939447
• pubmed:30002279
• pubmed:30658422
• pubmed:31652942
• pubmed:32606601
• pubmed:34028091
• pubmed:34156519
• pubmed:34922298
• pubmed:35195837
• pubmed:36098367
• pubmed:36341365
• pubmed:36479120
• pubmed:37470935
• pubmed:38697849

Ontology

ChEBI  ( EBI )