MK-2461

Term ID

CHEBI:230540

Synonyms

• 9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
• MK 2461
• MK2461
• N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfuric diamide

Definition

A member of the class of benzocycloheptapyridines that is 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one substituted by 1-methyl-1H-pyrazol-4-yl and [{[(2R)-1,4-dioxan-2-yl]methyl}(methyl)sulfamoyl]amino groups at positions 3 and 7, respectively. It is a novel ATP-competitive multi-targeted inhibitor of activated c-Met (IC₅₀ = 2.5 nM).

References

• cas:917879-39-1
• pubmed:19357798
• pubmed:20145145
• pubmed:20836672
• pubmed:21247903
• pubmed:21429632
• pubmed:21608528
• pubmed:25806189
• pubmed:26077488
• pubmed:26863403
• pubmed:28196027
• pubmed:29497919
• pubmed:30636579

Ontology

ChEBI  ( EBI )