fruquintinib

Term ID

CHEBI:229221

Synonyms

6-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide
fruquintinib
fruquintinibum
Fruzaqla
HMPL-013

Definition

A member of the class of quinazolines that is quinazoline substituted by [2-methyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]oxy, methoxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a highly potent and selective inhibitor of VEGFR 1, 2 and 3 (IC₅₀ = 33, 0.35, and 35 nM) used for the treatment of metastatic colorectal cancer.

References

cas:1194506-26-7
drugbank:DB11679
kegg.drug:D11977
pmc:PMC10955531
pubmed:33247124
pubmed:33993740
pubmed:33998237
pubmed:34077681
pubmed:35063062
pubmed:35216918
pubmed:35482571
pubmed:35862249
pubmed:36331272
pubmed:36470443
pubmed:36539356
pubmed:36623495
pubmed:36628898
pubmed:36760383
pubmed:36937443
pubmed:36982913
pubmed:37084488
pubmed:37193166
pubmed:37275454
pubmed:37331369
pubmed:37364727
pubmed:37581770
pubmed:37771923
pubmed:37796398
pubmed:37842200
pubmed:38024475
pubmed:38051798
pubmed:38063405
pubmed:38112011
pubmed:38130300
pubmed:38196522
pubmed:38196544
pubmed:38202064
pubmed:38341203
pubmed:38346904
pubmed:38412270
pubmed:38497279
pubmed:38524525
pubmed:38568032
wikipedia.en:Fruquintinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from fruquintinib

Phenotype where environments contain fruquintinib

Phenotype modified by environments containing fruquintinib

Phenotype affecting fruquintinib

Human Disease Model