nirogacestat

Term ID

CHEBI:229217

Synonyms

(2S)-2-{[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino}-N-(1-{1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl}-1H-imidazol-4-yl)pentanamide
(S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
N(2)-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-N-(1-{1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl}-1H-imidazol-4-yl)-L-norvalinamide
nirogacestat
nirogacestatum
PF-03084014
PF-3084014

(all 7)

Definition

A member of the class of imidazoles that is 1H-imidazole substituted by a 1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl group at position 1 and a {N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-L-norvalyl}amino group at position 4. It is a gamma-secretase inhibitor whose hydrobromide salt is indicated for adult patients with progressing desmoid tumours who require systemic treatment.

References

(all 37)

Ontology

ChEBI ( EBI )

Relationships

is a type of: imidazoles organofluorine compound secondary amino compound secondary carboxamide tetralins

imidazoles organofluorine compound secondary amino compound secondary carboxamide tetralins Show first 5 Terms
has_role: antineoplastic agent gamma-secretase modulator

antineoplastic agent gamma-secretase modulator Show first 5 Terms
inverse is_conjugate_acid_of: nirogacestat(2+)

nirogacestat(2+) Show first 5 Terms
is_conjugate_base_of: nirogacestat(2+)

nirogacestat(2+) Show first 5 Terms

Phenotype

Phenotype resulting from nirogacestat

Phenotype where environments contain nirogacestat

Phenotype modified by environments containing nirogacestat

Phenotype affecting nirogacestat

Human Disease Model