KRIBB11

Term ID

CHEBI:228800

Synonyms

N(2)-(1H-indazol-5-yl)-N(6)-methyl-3-nitropyridine-2,6-diamine
N(2)-1H-indazol-5-yl-N(6)-methyl-3-nitro-2,6-pyridinediamine

Definition

A member of the class of indazoles that is 1H-indazole substituted by a [6-(methylamino)-3-nitropyridin-2-yl]amino group at position 5. It is an inhibitor of heat shock factor 1 (IC50 = 1.2muM) and suppresses tumour growth in mouse xenograft models.

References

(all 24)

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopyridine aromatic amine C-nitro compound indazoles

aminopyridine aromatic amine C-nitro compound indazoles Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer heat shock factor 1 inhibitor

antineoplastic agent apoptosis inducer heat shock factor 1 inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from KRIBB11

Phenotype where environments contain KRIBB11

Phenotype modified by environments containing KRIBB11

Phenotype affecting KRIBB11

Human Disease Model