LLY-507

Term ID

CHEBI:228258

Synonyms

• 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl][biphenyl]-3-carboxamide
• LLY 507
• LLY507

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}[biphenyl]-3-carboxylic acid with the amino group of 3-(pyrrolidin-1-yl)propan-1-amine. It is a potent and selective inhibitor of SMYD2 and inhibits the ability of SMYD2 to methylate p53. It serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.

References

• cas:1793053-37-8
• pubmed:25825497
• pubmed:30955858
• pubmed:31730617
• pubmed:33011288
• pubmed:33407870
• pubmed:34510321
• pubmed:36270984
• pubmed:37513898
• pubmed:37524453

Ontology

ChEBI  ( EBI )