KU-60019

Term ID

CHEBI:228206

Synonyms

2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-N-{5-[6-(morpholin-4-yl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl}acetamide
KU 60019
KU60019

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of [(2R,6S)-2,6-dimethylmorpholin-4-yl]acetic acid with the amino group of 2-(7-amino-9H-thioxanthen-4-yl)-6-(morpholin-4-yl)-4H-pyran-4-one. It is an ATM kinase inhibitor (IC50 = 6.3 nM).

References

(all 27)

Ontology

ChEBI ( EBI )

Relationships

is a type of: 4-pyranones morpholines secondary carboxamide tertiary amino compound thioxanthenes

4-pyranones morpholines secondary carboxamide tertiary amino compound thioxanthenes Show first 5 Terms
has_role: antineoplastic agent autophagy inducer EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor radiosensitizing agent

antineoplastic agent autophagy inducer EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor radiosensitizing agent Show first 5 Terms

Phenotype

Phenotype resulting from KU-60019

Phenotype where environments contain KU-60019

Phenotype modified by environments containing KU-60019

Phenotype affecting KU-60019

Human Disease Model