carbovir

Term ID

CHEBI:202940

Synonyms

• (+-)-carbovir
• 2-amino-9-[rel-(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-1,9-dihydro-6H-purin-6-one
• 2-amino-9-[rel-(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-9H-purin-6-ol
• carbovir
• cis-(+-)-2-amino-1,9-dihydro-9-(4-(hydroxymethyl)-2-cyclopenten-1-yl)-6H-purin-6-one
• cis-2-amino-1,9-dihydro-9-(4-(hydroxymethyl)-2-cyclopenten-1-yl)-6H-purin-6-one
• cis-2-amino-9-(4-hydroxymethylcyclopent-2-enyl)-9H-purin-6-ol

Definition

Cyclopent-2-en-1-ylmethanol in which the 4-position is substituted by a 2-amino-6-hydroxy-9H-purin-9-yl group such that the two substitutents on the cyclopentene ring are in a cis relationship. The (-)-enantiomer, also known as carbovir, is a potent inhibitor of HIV replication replication in cell cultures.

References

• CAS:118353-05-2
• PMID:15916425
• PMID:18549801
• PMID:2296018

Ontology

ChEBI  ( EBI )