INDY

Term ID

CHEBI:195332

Synonyms

(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)propan-2-one
(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
(1Z)-1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone

Definition

A member of the class of benzothiazoles that is 2,3-dihydro-1,3-benzothiazole substituted by 2-oxopropylidene, ethyl, and hydroxy groups at positions 2, 3 and 5, respectively. It is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B (IC50 of 0.24 muM and 0.23 muM, respectively).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzothiazoles enone organic hydroxy compound

benzothiazoles enone organic hydroxy compound Show first 5 Terms
has_role: antineoplastic agent drug metabolite EC 2.7.12.1 (dual-specificity kinase) inhibitor

antineoplastic agent drug metabolite EC 2.7.12.1 (dual-specificity kinase) inhibitor Show first 5 Terms
inverse has_functional_parent: proINDY

proINDY Show first 5 Terms

Phenotype

Phenotype resulting from INDY

Phenotype where environments contain INDY

Phenotype modified by environments containing INDY

Human Disease Model