7-methyl-guanosine-5'-triphosphate-5'-guanosine

Term ID

CHEBI:191209

Synonyms

2-amino-9-[(2R,3R,4S,5R)-5-({[{[{[{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-me
7-methyl-diguanosine triphosphate
7-methyl-GpppG
[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-7-ium-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] hydrogen phosphate
m(7)G(5')ppp(5')G
m(7)GP3G
m(7)GP3G (monomethylated cap analog)
m(7)GpppG
mRNA cap analog N(7)-methyl GpppG
N(7)-MeGpppG
P(1)-(5'-7-methyl-guanosyl) P(3)-(5'-(guanosyl))triphosphate

Definition

A guanosine 5'-phosphate that is 7-methyl-GTP in which the hydroxy group of the terminal phosphate is substituted by a guanosinyl group. It is a cap analog that can be incorporated into mRNA.

References

cas:62828-64-2
chemspider:108799
drugbank:DB03958
patent:WO2017066781
pdb-ccd:GTG
pubmed:10981813
pubmed:11156290
pubmed:12374755
pubmed:12454499
pubmed:12464184
pubmed:14731396
pubmed:15068804
pubmed:16767703
pubmed:17363367
pubmed:18066781
pubmed:18614538
pubmed:19217398
pubmed:19269171
pubmed:19710013
pubmed:22316555
pubmed:22985415
pubmed:25150228
pubmed:25228490
pubmed:25834778
pubmed:26294658
pubmed:26559973
pubmed:26779415
pubmed:27236792
pubmed:32950529

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from 7-methyl-guanosine-5'-triphosphate-5'-guanosine

Phenotype where environments contain 7-methyl-guanosine-5'-triphosphate-5'-guanosine

Phenotype modified by environments containing 7-methyl-guanosine-5'-triphosphate-5'-guanosine

Phenotype affecting 7-methyl-guanosine-5'-triphosphate-5'-guanosine

Human Disease Model