niraparib

Term ID

CHEBI:176844

Synonyms

2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide
2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
MK 4827
MK-4827
MK4827
niraparib
niraparibum
Zejula

(all 9)

Definition

A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.

References

(all 40)

Ontology

ChEBI ( EBI )

Relationships

is a type of: 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide

2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor radiosensitizing agent

antineoplastic agent apoptosis inducer EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor radiosensitizing agent Show first 5 Terms

Phenotype

Phenotype resulting from niraparib

Phenotype where environments contain niraparib

Phenotype modified by environments containing niraparib

Phenotype affecting niraparib

Human Disease Model